PROTECTIVE ROLE OF HYPERLIPIDEMIA IN MICROBIAL INJURY

 

The hyperlipidemic (hyperlipoproteinemia) response has so far only been interpreted as the cause of atherosclerosis, its protective role in human health, including protecting against atherosclerosis, has not been fully appreciated.

Lipoproteins, for so long considered to be without purpose commensurate with their complexity, are increasingly being found to possess the unique properties of being able to inactivate the pathogenicity of microbes, bind microbial toxic components such as microbial cell wall lipopolysaccharides, and bind microbial toxins. The binding of toxins decreases the potential of the toxin's cytotoxicity as is well documented by the use of orally administered activated charcoal to bind ingested poisons.

The indiscriminate lowering of one's lipoproteins may actually result in increased atherosclerosis (WHO and Finland Long Term Studies).

 

Lipoproteins Induce Humoral Immunity To Infection.

Schouls et al (1989) found that lipoproteins appeared to play an important role in the process of the induction of humoral immunity in infections.

Apolipoprotein AI Inhibit HIV Cytotoxicity.

Owens et al (1990) found that apolipoprotein AI, the major protein component of high density lipoprotein, provides significant protection against HIV-1 and vaccina viruses by inhibiting their cytotoxicity. They suggested that this protective property of the apolipoprotein could have potential implications for HIV therapy. The hyperlipidemia found in AIDS patients may be a reflection of activation of this protective property.
 
 

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